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Evidence is increasing that addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err on the side of caution and allow FDA do its job and demand some investigation be done so that the public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies have been in business to earn money and that they would say almost anything to keep people on the medications.

Researchers found out that participants using this drug to get a year, lost weight within one month and have kept the body weight off during the entire 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, that might make them far better and safer.

Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that by right now there aren't long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug can also raise blood pressure levels and pulse rate, and really should not be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must not used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.


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